منابع مشابه
Metronidazole neuropathy.
Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively. The drug, widely used in gastroenterological and gynaecological practice, has not hitherto been considered neurotoxic. The implications are stressed in relation to the differential diagnosis of patients with gastroenterological disorders who develop peripheral neuropathy.
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372 CMYK limbs versus the lower extremities (cruciate palsy, brachial diplegia) is seen in the traumatic central cord syndrome or cervical spondylotic myelopathy of elderly patients. Brachial diplegia due to pyramidal tract involvement was first described by Mohr, while the term man-in-the-barrel syndrome (MIBS) was coined by Sage and Van Clitert to describe the clinical aspect of the patient w...
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Extraintestinal manifestations are not uncommon in Crohn's disease, and a thromboembolic event is a disastrous potential complication. Deep vein thrombosis is the most common manifestation of a thromboembolic event and typically occurs in association with active inflammatory disease. Peripheral neuropathy in Crohn's disease has rarely been reported and is considered an adverse effect of metroni...
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Since metronidazole is so widely used, it is important to know whether there is any risk from giving the drug during pregnancy. Many drugs are now withheld during early pregnancy, unless their administration is considered essential. There are, however, patients to whom drugs are given before the existence of pregnancy is recognized. In such cases there may be risks of foetal malformations. Apar...
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Bioavailability File: Metronidazole Summary Metronidazole is an antimicrobial nitroimidazole derivative, which was originally introduced to treat Trichomonas vaginalis but nowadays is used for the treatment of anaerobic and protozoal infections. Metronidazole is bactericidal through toxic metabolites, which cause deoxyribonucleic acid (DNA) strand breakage. It has a bioavailability of more than...
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6087.610